Disease-related complications in patients with metastatic hormone-sensitive prostate cancer
Publication in refereed journal
CUHK Authors
Full Text
View Full-text in CUHK Digital Object Identifier (DOI) ![]() |
Altmetrics Information
.
Other information
AbstractIntroduction: Prostate-specific antigen-based screening for prostate cancer reportedly does not improve cancer-specific survival. However, there remain concerns about the increasing incidence of advanced disease at initial presentation. Here, we investigated the incidences and types of complications that occur during the course of disease in patients with metastatic hormone-sensitive prostate cancer (mHSPC).Methods: This study included 100 consecutive patients who were diagnosed with mHSPC at five hospitals from January 2016 to August 2017. Analyses were conducted using patient data extracted from a prospectively collected database, along with information about complications and readmission obtained from electronic medical records.Results: The median patient age was 74 years and the median serum prostate-specific antigen level at diagnosis was 202.5 ng/mL. Ninety-nine patients received androgen deprivation therapy; 17 of these patients also received chemotherapy. During a mean follow-up period of 32.9 months, 41 patients reported bone pain; of these patients, 21 developed pathologic fractures and eight had cord compression. Twenty-eight patients developed retention of urine; of these patients, 10 (36%) required surgery and 11 (39%) required long-term urethral catheter use. Among 15 patients who developed ureteral obstruction, four (27%) required ureteral stenting and four (27%) required long-term nephrostomy drainage. Other complications included anaemia (41%) and deep vein thrombosis (4%). Fifty-nine (59%) patients had & GE;1 unplanned hospital admission during the course of disease; 16% of such patients had >5 episodes of readmission.Conclusion: Among patients with mHSPC, 70% experienced disease-related complications and unplanned hospital admissions, which substantially burdened both patients and the healthcare system.
All Author(s) ListNg CF, Mak CWH, Chan SYS, Li ML, Leung CH, Teoh JYC, Chiu PKF, Chu PSK
Journal nameHong Kong Medical Journal
Year2023
Month8
Volume Number29
Issue Number4
PublisherHong Kong Academy of Medicine
Pages324 - 329
ISSN1024-2708
LanguagesEnglish-United Kingdom
KeywordsBone diseases, Prostate-specific antigens, Prostatic neoplasmss, Ureteral obstruction, Urinary retention