Carnobacterium maltaromaticum boosts intestinal vitamin D production to suppress colorectal cancer in female mice
Publication in refereed journal
香港中文大學研究人員
全文
替代計量分析
.
其它資訊
摘要Carnobacterium maltaromaticum was found to be specifically depleted in female patients with colorectal cancer (CRC). Administration of C. maltaromaticum reduces intestinal tumor formation in two murine CRC models in a female-specific manner. Estrogen increases the attachment and colonization of C. maltaromaticum via increasing the colonic expression of SLC3A2 that binds to DD-CPase of this bacterium. Metabolomic and transcriptomic profiling unveils the increased gut abundance of vitamin D-related metabolites and the mucosal activation of vitamin D receptor (VDR) signaling in C. maltaromaticum-gavaged mice in a gut microbiome- and VDR-dependent manner. In vitro fermentation system confirms the metabolic cross-feeding of C. maltaromaticum with Faecalibacterium prausnitzii to convert C. maltaromaticum-produced 7-dehydrocholesterol into vitamin D for activating the host VDR signaling. Overall, C. maltaromaticum colonizes the gut in an estrogen-dependent manner and acts along with other microbes to augment the intestinal vitamin D production to activate the host VDR for suppressing CRC.
出版社接受日期29.06.2023
著者Qing Li, Hung Chan, Wei-Xin Liu, Chang-An Liu, Yunfei Zhou, Dan Huang, Xueliang Wang, Xiaoxing Li, Chuan Xie, Wing Ying-Zhi Liu, Xian-Song Wang, Siu Kin Ng, Hongyan Gou, Liu-Yang Zhao, Winnie Fong, Lanping Jiang, Yufeng Lin, Guijun Zhao, Feihu Bai, Xiaodong Liu, Huarong Chen, Lin Zhang, Sunny Hei Wong, Matthew Tak Vai Chan, William Ka Kei Wu, Jun Yu
期刊名稱Cancer Cell
出版年份2023
月份8
日期14
卷號41
期次8
頁次1450 - 1465.e8
國際標準期刊號1535-6108
電子國際標準期刊號1878-3686
語言英式英語
