Using chromosomal status instead of embryo morphology for better outcomes - a local experience from Preimplantation Genetic Testing (PGT)
Refereed conference paper presented and published in conference proceedings


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AbstractIntroduction: Morphological assessment is widely used to select competent embryos. In recent years, PGT, in the
form of aneuploidy screening, has been shown to improve implantation and clinical pregnancy rates in young and good prognosis patients. Its potential benefits in patients with other etiology have yet to be demonstrated.
Objectives: To audit our PGT program by (1) reviewing the morphology and ploidy status of all embryos subjected to PGT; (2) evaluating success rates of euploid/normal embryos after intrauterine transfer.
Methodology: This is a retrospective review of all PGT cycles from December 2014 to December 2016 in one university hospital infertility centre.
Results: There were 37 PGT cycles during the study period. The women had a mean age of 37.0 years (range 24 to 45), requesting aneuploidy screening alone due to advanced maternal age (AMA, age>35 years), recurrent miscarriage, or together with pre-implantation genetic diagnosis because of having an affected pregnancy, and/or being a carrier of a monogenic disorder. Among 190 embryos biopsied at cleavage or blastocyst stage, 23.7 % were euploids, 63.7 % were aneuploids, 3.7 % were not tested due to disease-affected status, and 8.9 % with no or inconclusive results. Embryo morphology, as assessed by embryo cell number or an established blastocyst grading system (Gardner), had no statistical difference between euploid and aneuploidy embryos. Nineteen euploid/normal embryos were transferred in 17 patient cycles, resulting in implantation and ongoing pregnancy rates of 73.7 % and 64.7 %, respectively.
Conclusion:Our data concluded that the morphology of an embryo was not predictive of its chromosomal status. A good-quality embryo, as judged by its morphology, might not necessarily be a euploid, and vice versa. Good implantation and ongoing pregnancy rates could be achieved after PGT for patients with AMA, recurrent
miscarriage, and/or a known genetic cause.
All Author(s) ListYeung QSY, Kong GWS, Kwok YKY, Li TC, Choy KW
Name of ConferenceThe 25th Asian & Oceanic Congress of Obstetrics & Gynaecology
Start Date of Conference15/06/2017
End Date of Conference18/06/2017
Place of ConferenceHong Kong
Country/Region of ConferenceHong Kong
Proceedings TitleThe Journal of Obstetrics and Gynaecology Research
Year2017
Month6
Volume Number43
Issue NumberS1
PublisherJapan Society of Obstetrics and Gynecology and Editors
Place of PublicationHong Kong
Pages154 - 155
LanguagesEnglish-United States

Last updated on 2018-18-01 at 08:22