Decision Support System for Chronic Diseases Based on Drug-Drug Interactions
Refereed conference paper presented and published in conference proceedings

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AbstractMany patients with chronic diseases resort to multiple medications to relieve various symptoms, which raises concerns about the safety of multiple medication use, as severe drug-drug antagonism can lead to serious adverse effects or even death. This paper presents a Decision Support System, called DSSDDI, based on drug-drug interactions to support doctors prescribing decisions. DSSDDI contains three modules, Drug-Drug Interaction (DDI) module, Medical Decision (MD) module and Medical Support (MS) module. The DDI module learns safer and more effective drug representations from the drug-drug interactions. To capture the potential causal relationship between DDI and medication use, the MD module considers the representations of patients and drugs as context, DDI and patients’ similarity as treatment, and medication use as outcome to construct counterfactual links for the representation learning. Furthermore, the MS module provides drug candidates to doctors with explanations. Experiments on the chronic data collected from the Hong Kong Chronic Disease Study Project and a public diagnostic data MIMIC-III demonstrate that DSSDDI can be a reliable reference for doctors in terms of safety and efficiency of clinical diagnosis, with significant improvements compared to baseline methods. Source code of the proposed DSSDDI is publicly available at
Acceptance Date14/02/2023
All Author(s) ListTian Bian, Yuli Jiang, Jia Li, Tingyang Xu, Yu Rong, Yi Su, Timothy Kwok, Helen Meng, Hong Cheng
Name of ConferenceInternational Conference on Data Engineering
Start Date of Conference03/04/2023
End Date of Conference07/04/2023
Place of ConferenceAnaheim, CA
Country/Region of ConferenceUnited States of America
Proceedings Title2023 IEEE 39th International Conference on Data Engineering (ICDE)
Place of PublicationCalifornia
Pages3467 - 3480
LanguagesEnglish-United States
KeywordsDecision Support System, Drug-Drug Interactions, Causal Inference

Last updated on 2024-31-01 at 15:17