The adjuvant value of Andrographis paniculata in metastatic esophageal cancer treatment–from preclinical perspectives
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AbstractEsophageal cancer (EC) is the fourth and sixth leading cause of cancer-related deaths in China and United States, respectively. The dismal prognosis of EC is mainly attributed to distant metastases, which may not be overcome by chemotherapy alone. Hence, the use of alternative adjuvant treatments, such as herbal medicines, for metastatic EC remains a great desire of patients. Our previous study demonstrated the in vivo anti-tumor and in vitro anti-invasion activities of Andrographis paniculata (AP) in esophageal cancer. In the present study, the chemical constituents of absorbed AP components through human intestinal Caco-2 cell monolayer were verified for the first time. The anti-migratory activities and suppressive effects on metastasis-related factors such as HER2, MMP2, MMP9, TM4SF3, CXCR4 of the absorbed AP components were revealed in esophageal cancer cells EC-109. The anti-tumor and anti-metastatic effects of AP water extract (1600 mg/kg) were further confirmed in metastatic esophageal xenograft-bearing mice. Besides, AP water extract acted synergistically with cisplatin plus 5-fluorouracil on inhibiting tumor nodule growth (with combination index <0.7). Meanwhile, chemotherapeutics-induced side-effects could also be reduced by AP water extract. The present findings provide evidence on safety and advantages of the combined use of AP with chemotherapeutics in pre-clinical setting.
All Author(s) ListLin LI, Grace Gar-Lee YUE, Julia Kin-Ming LEE, Eric Chun-Wai WONG, Kwok-Pui FUNG, Jun YU, Clara Bik-San LAU, Philip Wai-Yan CHIU
Journal nameScientific Reports
Year2017
Month4
Day12
Volume Number7
PublisherNature Publishing Group
Pages854
ISSN2045-2322
eISSN2045-2322
LanguagesEnglish-United Kingdom
KeywordsOesophageal cancer, Translational research

Last updated on 2020-20-10 at 03:32