The role of metabolic reprogramming in γ‐herpesvirus‐associated oncogenesis
Publication in refereed journal

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摘要The γ-herpesviruses, EBV and KSHV, are closely associated with a number of human cancers. While the signal transduction pathways exploited by γ-herpesviruses to promote cell growth, survival and transformation have been reported, recent studies have uncovered the impact of γ-herpesvirus infection on host cell metabolism. Here, we review the mechanisms used by γ-herpesviruses to induce metabolic reprogramming in host cells, focusing on their ability to modulate the activity of metabolic regulators and manipulate metabolic pathways. While γ-herpesviruses alter metabolic phenotypes as a means to support viral infection and long-term persistence, this modulation can inadvertently contribute to cancer development. Strategies that target deregulated metabolic phenotypes induced by γ-herpesviruses provide new opportunities for therapeutic intervention.
著者Lo AK, Dawson CW, Young LS, Lo KW
期刊名稱International Journal of Cancer
出版作品名稱International Journal of Cancer
出版年份2017
月份10
日期15
卷號141
期次8
出版社Wiley
頁次1512 - 1521
國際標準期刊號0020-7136
語言英式英語

上次更新時間 2020-27-11 於 02:11