Motor-assisted chip-in-a-tube (MACT): a new 2- and 3-dimensional centrifugal microfluidic platform for biomedical applications
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AbstractCurrently, centrifuge apparatus is primarily an end-point sample processing piece of equipment. The lack of real-time active control has imposed an inherent limitation such that many delicate sample processing steps requiring immediate and accurate intervention have never been possible. We report herein a motor- assisted chip-in-a-tube (MACT) platform in which a microfluidic chip placed inside a common centrifuge canister can be rotated through wireless control in order to manipulate the centrifugal force vector in a 3-dimensional (3D) manner. As a demonstration experiment, we have used our MACT prototype to per- form the operation for two common biomedical procedures, namely human blood plasma separation and E. coli plasmid DNA extraction. This simple, yet highly effective and versatile approach may serve as a ge- neric one-for-all platform for a wide range of common laboratory experiments and bioassay applications.
All Author(s) ListMinghui Tang, Jacky Fong-Chuen Loo, Yuye Wang, Xuping Zhang, Ho-Chin Kwok, Mamie Hui, Czarina Chi-Hung Leung, Siu-Kai Kong Guanghui Wang, Ho-Pui Ho
Journal nameLab on a Chip
Volume Number17
Issue Number3
Pages474 - 483
LanguagesEnglish-United Kingdom

Last updated on 2020-18-09 at 02:26