Injectable magnesium oxychloride cement foam-derived scaffold for augmenting osteoporotic defect repair
Publication in refereed journal


摘要Hypothesis: Cement augmentation has been widely applied to promote osteoporotic fracture healing, whereas the existing calcium-based products suffer from the excessively slow degradation, which may impede bone regeneration. Magnesium oxychloride cement (MOC) shows promising biodegradation ten-dency and bioactivity, which is expected to be a potential alternative to the classic calcium-based cement for hard-tissue-engineering applications. Experiments: Here, a hierarchical porous MOC foam (MOCF)-derived scaffold with favorable bio-resorption kinetic and superior bioactivity is fabricated through Pickering foaming technique. Then, a sys-tematic characterization in terms of material properties and in vitro biological performance have been conducted to evaluate the feasibility of the as-prepared MOCF scaffold to be a bone-augmenting material for treating osteoporotic defects. Findings: The developed MOCF shows excellent handling performance in the paste state, while exhibiting sufficient load-bearing capacity after solidification. In comparison with the traditional bone cement, cal-cium deficient hydroxyapatite (CDHA), our porous MOCF scaffold demonstrates a much higher biodegra-dation tendency and better cell recruitment ability. Additionally, the eluted bioactive ions by MOCF commits to a biologically inductive microenvironment, where the in vitro osteogenesis is significantly enhanced. It is anticipated that this advanced MOCF scaffold will be competitive for clinical therapies to augment osteoporotic bone regeneration.
著者Zhu YW, Guo JX, Sheng YF, Xu JK, Qin L, Ngai T
期刊名稱Journal of Colloid and Interface Science
頁次199 - 210
關鍵詞Magnesium oxychloride cement foam, Pickering foaming technique, 3D hierarchical porous scaffold, Bone regeneration, Osteoporotic bone repair
Web of Science 學科類別Chemistry, Physical;Chemistry

上次更新時間 2024-09-04 於 00:10