Injectable magnesium oxychloride cement foam-derived scaffold for augmenting osteoporotic defect repair
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AbstractHypothesis: Cement augmentation has been widely applied to promote osteoporotic fracture healing, whereas the existing calcium-based products suffer from the excessively slow degradation, which may impede bone regeneration. Magnesium oxychloride cement (MOC) shows promising biodegradation ten-dency and bioactivity, which is expected to be a potential alternative to the classic calcium-based cement for hard-tissue-engineering applications. Experiments: Here, a hierarchical porous MOC foam (MOCF)-derived scaffold with favorable bio-resorption kinetic and superior bioactivity is fabricated through Pickering foaming technique. Then, a sys-tematic characterization in terms of material properties and in vitro biological performance have been conducted to evaluate the feasibility of the as-prepared MOCF scaffold to be a bone-augmenting material for treating osteoporotic defects. Findings: The developed MOCF shows excellent handling performance in the paste state, while exhibiting sufficient load-bearing capacity after solidification. In comparison with the traditional bone cement, cal-cium deficient hydroxyapatite (CDHA), our porous MOCF scaffold demonstrates a much higher biodegra-dation tendency and better cell recruitment ability. Additionally, the eluted bioactive ions by MOCF commits to a biologically inductive microenvironment, where the in vitro osteogenesis is significantly enhanced. It is anticipated that this advanced MOCF scaffold will be competitive for clinical therapies to augment osteoporotic bone regeneration.
All Author(s) ListZhu YW, Guo JX, Sheng YF, Xu JK, Qin L, Ngai T
Journal nameJournal of Colloid and Interface Science
Year2023
Month6
Volume Number640
PublisherACADEMIC PRESS INC ELSEVIER SCIENCE
Pages199 - 210
ISSN0021-9797
eISSN1095-7103
LanguagesEnglish-United Kingdom
KeywordsMagnesium oxychloride cement foam, Pickering foaming technique, 3D hierarchical porous scaffold, Bone regeneration, Osteoporotic bone repair
Web of Science Subject CategoriesChemistry, Physical;Chemistry
