Aberrant expression of novel cytokine IL-38 and regulatory T lymphocytes in childhood asthma
Invited conference paper presented and published in conference proceedings


全文

其它資訊
摘要Background: The role of the newly identified cytokine IL-38 and it’s relationship with regulatory T cells in asthma is not clear.
Methods: We investigated the expression of novel anti-inflammatory interleukin (IL)-38 and regulatory T (Treg) lymphocytes in childhood asthma patients. The protein and mRNA expression level of IL-38, periostin, peripheral CD4+CD25+CD134+ T lymphocytes as well as CD4+CD25highFoxP3+ and CD4+CD25highCD127- Treg lymphocytes from asthmatic patients and controls.
Results: 40 asthmatic patients and 20 normal control (NC) subjects were studied using ELISA, qPCR and flow cytometry. Serum and supernatant cytokines/chemokines were determined by multiplex assay. Serum IL-38, IL-5, IL-17, IL-6, interferon-γ, periostin, IL-1β and IL-13 concentrations were significantly higher in asthmatic patients with or without steroid treatment than those in controls (all p < 0.05). The percentages of both CD4+CD25highFoxP3+ and CD4+CD25highCD127- Treg lymphocytes were markedly decreased in asthmatic patients with and without steroid treatment than those in controls (all p < 0.05). The percentage of CD4+CD25+CD134+ activated T lymphocytes was also significantly higher in asthmatic patients with steroid treatment than those in controls (p < 0.05).
Conclusion: This study demonstrated that the overexpression of circulating IL-38 may play a role in the immunopathogenesis in asthma.
著者Miranda SM Tsang, Anna Lin, Michelle Yu, Edmund Yung, Chun K Wong, Gary WK Wong
會議名稱The 53rd Annual Meeting of Japanese Society of Pediatric Allergy and Clinical Immunology
會議開始日08.10.2016
會議完結日09.10.2016
會議地點Maebashi, Gunma, Japan
會議國家/地區日本
會議論文集題名The prospects of the treatment to the future
出版年份2016
頁次122 - 123
語言英式英語

上次更新時間 2018-06-07 於 11:16