Reduce Expression of Chemokines in Experimental Model of Valproic Acid induced Autism
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Abstract(Background and Objective) Autism Spectrum Disorder (ASD) is a social communication deficit and restricted & repetitive behavior. Current prevalence is 26.6 per 10,000 in Hong Kong, Taiwan and mainland China. ASD correlates with immune system in brain. Abnormal microglial activation and reduced numbers of T-lymphocytes in blood were found in autistic patients. Chemokines activate monocytes, macrophages and natural killer cells in immune system as well as microglia in central nervous system. However, the role of chemokine in brain of autistic patient is still unclear. Valproic acid (VPA) was reported to increase risk of ASD in clinical studies and experimental animal model. In this study, roles of chemokine (c-c motif) ligands and receptors in the cerebral cortex of VPA-induced autism mice were investigated. (Materials) VPA was injected intraperitoneally into pregnant Balb/c mice with a dosage of 600 mg/kg on embryonic day (E) 12.5. Sociability of pups was examined on postnatal days (PND) 28, 35, and 49 using three-chamber sociability test. Gene expression of chemokines in cerebral cortex was carried out on PND 50 using real-time PCR. (Result) VPA treated pups showed less sociability throughout adolescence to young adult stage in three-chamber behavior test. Gene expression levels of CCL2, CCR2, CCL3, CCL4 and CCR4 in cerebral cortex of VPA-induced ASD group were downregulated significantly compared with PBS control group on PND 50. (Conclusion) Reduction of chemokines synthesis may lead to immune dysfunction in cerebral cortex of autism
All Author(s) ListMA S.Y., YANG W., CHAU D.K.F., CHAN C.W.
Name of ConferenceThe 14th Asia Pacific Multidisciplinary Meeting for Nervous System Diseases: Brain 2017
Start Date of Conference05/01/2017
End Date of Conference07/01/2017
Place of ConferenceHong Kong
Country/Region of ConferenceHong Kong
LanguagesEnglish-United Kingdom

Last updated on 2018-18-01 at 03:07