Vitamin D and Cancer Stem Cells in the Gastrointestinal Tract
Publication in refereed journal


摘要Vitamin D has been widely used as a dietary supplement for the prevention and treatment of bone disorders. Epidemiological and preclinical studies demonstrated the anticancer action of vitamin D in a variety of cancers including those in the gastrointestinal (GI) tract. In these studies the inhibitory action of vitamin D on cancer stem cells (CSCs) has been a focus and is also an important subject to revolutionize the therapeutic potential of vitamin D on cancer treatment. Here, we summarize the involvement of CSC markers and factors and also their signaling pathways in the development of cancers in the esophagus, stomach, colon, pancreas and also liver. It is also evidenced that vitamin D could inhibit these markers and factors and their related signaling pathways to suppress tumor progression. All these information could provide new strategies in repurposing vitamin D as therapeutic agent to inhibit cancers in the GI tract.
著者Mingxing LI, Longfei LI, Lin ZHANG, Zhangang XIAO, Jing SHEN, Wei HU, Qiang ZENG, Chi Hin CHO
期刊名稱Current Medicinal Chemistry
詳細描述No free download of the publication
頁次918 - 927
關鍵詞Vitamin D, gastrointestinal cancer, cancer stem cells, cancer stem cell markers, cancer microenvironment

上次更新時間 2021-27-01 於 01:37