Biodegradable Magnesium Pins for Fixation of Transverse Patella Fracture in Rabbits
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AbstractMagnesium (Mg) is a biodegradable metal that enhances fracture healing, However, fast degradation of Mg may weaken the implant before fracture is stable. Microarc oxidation (MAO) coating on metal surface resists corrosion. We hypothesise that Mg pins, with or without MAO, would enhance fracture healing mechanically and radiologically, while MAO would decrease degradation of Mg pins. Transverse osteotomy of patella was performed on female New Zealand White rabbits.Two parallel Mg pins, with or without MAO, were inserted alone the long axis of patella. Figure-of-eight tension band wire was applied for fracture fixation. Rabbits were sacrified at week 12. Microarchitecture and mechanical properties of the repaired patella were analysed with micro-computer tomography (microCT) and tensile testing, respectively. The degradation rate of the pins was measured with microCT. Compared with controls, the patella of Mg and Mg+MAO showed higher the tissue volumn (TV) and bone volume (BV) but lower in BV/TV ratio, TV density, and BV density. Mechanically, patella of Mg and Mg+MAO had higher failure load, ultimate strength, energy-to-failure, and stiffness than the controls. The volume of Mg pins and Mg+MAO pins decreased by 51.4% and 45.0%, respectively, but no significant difference was detected bewteen the groups. In conclusion, Mg pin, with or without MAO, enhanced the fracture healing of patella. However, the MAO coating did not reduce the corrosion of Mg pins at week 12. Assessments at earlier time points may be necessary to detect significant effect by MAO.
Acceptance Date01/09/2016
All Author(s) ListJL Wang, P Wan, K Yang, L Qin, DHK Chow
Name of ConferenceHKOA 36th Annual Conference
Start Date of Conference05/11/2016
End Date of Conference06/11/2016
Place of ConferenceHK
Country/Region of ConferenceHong Kong
LanguagesEnglish-United States

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