Black blood T1rho MR imaging may diagnose early stage liver fibrosis: a proof-of-principle study with rat biliary duct ligation model
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AbstractBackground: To explore black blood T1rho (T1ρ) liver imaging and investigate the earliest stage when biliary duct ligation (BDL) induced liver fibrosis can be diagnosed.

Methods: MR was performed at 3 Tesla. A T1ρ prepared 2D fast spin echo (FSE) sequence with acquisition of four spin lock times (TSLs: 1, 10, 30, and 50 msec) and spin-lock frequency of 500 Hz was applied. Inherent black blood effect of FSE and double inversion recovery (DIR) achieved blood signal suppression, and 3 axial sections per liver were obtained. Male Sprague-Dawley rats were scanned at baseline (n=32), and on day-3 (n=13), day-5 (n=11), day-7 (n=10), day-10 (n=4) respectively after BDL. Hematoxylin-eosin (HE) and picrosirius red staining liver histology was obtained at these time points.

Results: The physiological liver parenchyma T1ρ was 38.38±1.53 msec (range, 36.05–41.53 msec). Liver T1ρ value elevated progressively after BDL. On day-10 after BDL all experimental animals can be separated from normal liver based on T1ρ measurement with lowest value being 42.82 msec. Day-7 and day-10 liver resembled METAVIR stage-F1/F2 fibrosis, and fibrous area counted for 0.22%±0.13% and 0.38%±0.44% of liver parenchyma area, respectively.

Conclusions: This study provides the first proof-of-principle that T1ρ might diagnose early stage liver fibrosis.
All Author(s) ListKoon CM, Zhang X, Chen WT, Chu ESH, Lau CBS, Wang YXJ
Volume Number6
Issue Number4
PublisherAME PUBL CO
Pages353 - 363
LanguagesEnglish-United Kingdom
Keywordsbile duct obstruction, black blood, fibrosis, liver, T1rho (T1 rho)
Web of Science Subject CategoriesRadiology, Nuclear Medicine & Medical Imaging

Last updated on 2020-18-09 at 02:17