An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates
Publication in refereed journal


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摘要Nanomaterials for effective drug delivery require zero pre-release and on-demand release of therapeutic drugs. In this work we demonstrate a novel drug delivery system composed of a mesoporous silica platform conjugated to CuS nanoparticles with two complementary DNA sequences. CuS nanoparticles act as both gatekeepers preventing pre-release of drugs and photothermal agents for effective killing of cancer cells. This system exhibits temperature and NIR-responsive DOX release, with an additional accelerated release rate with GSH treatment. Therefore, it can act as an effective anticancer drug delivery carrier with triggered drug release and efficient anti-cancer effect in vitro after NIR irradiation.
著者Zhang L, Li YC, Jin ZX, Yu JC, Chan KM
期刊名稱Nanoscale
出版年份2015
卷號7
期次29
出版社ROYAL SOC CHEMISTRY
頁次12614 - 12624
國際標準期刊號2040-3364
語言英式英語
Web of Science 學科類別Chemistry; Chemistry, Multidisciplinary; Materials Science; Materials Science, Multidisciplinary; Nanoscience & Nanotechnology; Physics; Physics, Applied; Science & Technology - Other Topics

上次更新時間 2021-01-03 於 01:07