An NIR-triggered and thermally responsive drug delivery platform through DNA/copper sulfide gates
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AbstractNanomaterials for effective drug delivery require zero pre-release and on-demand release of therapeutic drugs. In this work we demonstrate a novel drug delivery system composed of a mesoporous silica platform conjugated to CuS nanoparticles with two complementary DNA sequences. CuS nanoparticles act as both gatekeepers preventing pre-release of drugs and photothermal agents for effective killing of cancer cells. This system exhibits temperature and NIR-responsive DOX release, with an additional accelerated release rate with GSH treatment. Therefore, it can act as an effective anticancer drug delivery carrier with triggered drug release and efficient anti-cancer effect in vitro after NIR irradiation.
All Author(s) ListZhang L, Li YC, Jin ZX, Yu JC, Chan KM
Journal nameNanoscale
Year2015
Volume Number7
Issue Number29
PublisherROYAL SOC CHEMISTRY
Pages12614 - 12624
ISSN2040-3364
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesChemistry; Chemistry, Multidisciplinary; Materials Science; Materials Science, Multidisciplinary; Nanoscience & Nanotechnology; Physics; Physics, Applied; Science & Technology - Other Topics

Last updated on 2020-07-08 at 02:07