Blockage of hydroxyl group partially abolishes the cholesterol-lowering activity of beta-sitosterol
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Abstractbeta-Sitosterol (SI) is hypocholesterolemic. The present study investigated whether the blockage of its hydroxyl group would abolish its cholesterol-lowering activity. The blockage was made by methylating and ethylating the hydroxyl group on C3 position, leading to formation of beta-sitosteryl 3 beta-methoxy (SM) and beta-sitosteryl 3 beta-ethoxy (SE) derivatives. Male hamsters were divided into five groups (n =8 each) and fed the non-cholesterol diet (NCD), high cholesterol diet containing 5 mmol of cholesterol (HCD), or one of the three high cholesterol experimental diets with addition of 5 mmol of SI (HCD + SI), 5 mmol of SM (HCD + SM) and 5 mmol of SE (HCD + SE), respectively, for 8 weeks. Results showed that SI could significantly reduce plasma total cholesterol (TC) by 17% (P < 0.05), while SM and SE had no effect on plasma TC. It was concluded that the hydroxyl group was essential for SI to render its cholesterol-lowering activity and its blockage abolished this ability. (C) 2014 Elsevier Ltd. All rights reserved.
All Author(s) ListWang XB, Huang WH, Lei L, Liu YW, Ma KY, Li YM, Wang LJ, Huang Y, Chen ZY
Journal nameJournal of Functional Foods
Year2015
Month1
Volume Number12
PublisherELSEVIER SCIENCE BV
Pages199 - 207
ISSN1756-4646
LanguagesEnglish-United Kingdom
Keywordsbeta-Sitosterol; beta-Sitosteryl 3 beta-ethoxy; beta-Sitosteryl 3 beta-methoxy; Cholesterol
Web of Science Subject CategoriesFood Science & Technology

Last updated on 2020-06-07 at 02:15