Melamine Impairs Renal and Vascular Function in Rats
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摘要Introduction: Recent outbreak and consequence of nephrotoxicity and kidney stone in infants previously exposed to melamine-contaminated milk products is unprecedentedly grave as little is actually unknown about the mechanistic process leading to pathophysiological alterations in renal function in affected children. Hypothesis: The present study investigates whether neonatal ingestion of melamine leads to renal and vascular dysfunction in adulthood; and whether ingestion of melamine in pregnant rats leads to renal dysfunction in their offspring.

Methods: A combination of approaches were employed including functional examination on vascular reactivity in isolated rat renal arteries, renal blood flow measurement by functional magnetic resonance imaging technique, assay for pro-inflammatory and fibrotic biomarkers, immunohistochemistry, and biochemical measurements of plasma and renal melamine.

Results: We provide novel mechanistic evidence demonstrating for the first time that melamine significantly reduces renal blood flow and impairs renal and vascular function associated with over-expression of pro-inflammatory markers, transforming growth factor-β1 (TGF-β1), bone morphogenic protein 4 (BMP4) and cyclooxygenase-2 (COX-2) in renal vasculature and kidney. Melamine also induces renal fibrosis and inflammatory changes. The present study provides scientific evidence revealing part of mechanisms by which melamine causes nephropathies in neonatal animals and impact on postnatal animals resulting from exposure to melamine during pregnancy.

Conclusions: We provide evidences supporting recent clinical observations of kidney stone and acute renal failure in infants consuming melamine-contaminated milk products and the possible mechanisms involved.
著者Wong WT, Tian XY, Wang YX, Chen ZY, Huang Y
會議名稱American Heart Association 2012
會議開始日03.11.2012
會議完結日07.11.2012
會議地點Los angeles
會議國家/地區美國
會議論文集題名Circulation
出版年份2012
月份11
日期20
卷號126
期次Suppl 21
出版社LIPPINCOTT WILLIAMS & WILKINS
頁次A16250 - A16250
國際標準期刊號0009-7322
電子國際標準期刊號1524-4539
語言英式英語
關鍵詞Endothelial function; Nutrition; Pharmacology; Renal circulation; Vascular
Web of Science 學科類別Cardiac & Cardiovascular Systems; Cardiovascular System & Cardiology; Peripheral Vascular Disease

上次更新時間 2021-17-01 於 01:50