Animal models of atherosclerosis (Review)
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AbstractAtherosclerosis is a significant cause of morbidity and mortality globally. Many animal models have been developed to study atherosclerosis, and permit experimental conditions, diet and environmental risk factors to be carefully controlled. Pathophysiological changes can be produced using genetic or pharmacological means to study the harmful consequences of different interventions. Experiments using such models have elucidated its molecular and pathophysiological mechanisms, and provided platforms for pharmacological development. Different models have their own advantages and disadvantages, and can be used to answer different research questions. In the present review article, different species of atherosclerosis models are outlined, with discussions on the practicality of their use for experimentation.
All Author(s) ListLee Y, Laxton V, Lin H, Chan Y, Fitzgerald-Smith S, To T, Yan B, Liu T, Tse G
Journal nameBiomedical Reports
Volume Number6
Issue Number3
PublisherSpandidos Publications
Pages259 - 266
LanguagesEnglish-United Kingdom

Last updated on 2021-17-10 at 00:08