Activation of the anti-tumor effector cells by Radix bupleuri
Publication in refereed journal

替代計量分析
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其它資訊
摘要Radix bupleuri, the root of Bupleuri spp., Chinese medicinal herbs used for the treatment of influenza, malaria and menstrual disorders, were extracted with hot water and separated into five different fractions (RB, RBI, RBII, RBIII and RBIV) by stepwise alcohol precipitation. One of these fractions, RBI, was then fractionated into RBIa and RBIb by gel filtration using G-100 Sephadex. These two fractions were further purified into RBIai, RBIaii and RBIbi, RBIbii fractions respectively by ion-exchange chromatography using DEAE-Sephadex. Each of these fractions is a heteropolymer consisting mainly of carbohydrate and varying proportions of protein and uronic acid. RBIaii was found to show strong anti-tumor activities in sarcoma-bearing mice. Mechanistic studies showed that RBIaii exhibited a potent activating effect on the cytotoxic activity of macrophages, NK and LAK cells against tumor cells. In addition, RBIaii could increase the number of tumor infiltrating lymphocytes (TILs) in the tumor site of WEHI-164-bearing mice. Furthermore, RBIaii could induce the release of interferon-γ by lymphocytes in vitro. © 1995.
著者Kok L.D.S., Wong C.K., Leung K.N., Tsang S.F., Fung K.P., Choy Y.M.
期刊名稱IMMUNOPHARMACOLOGY
出版年份1995
月份1
日期1
卷號30
期次1
出版社Elsevier BV
出版地Netherlands
頁次79 - 87
國際標準期刊號0162-3109
語言英式英語
關鍵詞Interferon-γ, Lymphokine activated killer cell, Macrophage, Natural killer cell, Radix bupleuri, Tumor infiltrating lymphocyte

上次更新時間 2020-04-08 於 01:05