Can We Predict Bone Quality and Bone Strength by Assessing Handgrip Muscle Strength in Normal Adolescents?
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摘要ABSTRACT INTRODUCTION: There are growing interest in the functional interaction between muscle and bone and between sarcopenia and osteoporosis. Previous studies using DXA and peripheral QCT found bone mass and muscle mass are highly correlated. With the use of high resolution peripheral quantitative computed tomography (HR-pQCT), Farr et al. also found that lean mass played an important role on optimizing bone strength during growth [1]. Although muscle mass correlated well with muscle strength, the relationship between the muscle strength and bone strength is not well understood. The objective of this study was to evaluate the correlation between muscle strength and bone quality in adolescents after adjusted for maturity and body size.

METHODS: Two hundred and sixteen normal boys and 335 girls aged 7 to 17 years were randomly recruited from local primary and secondary school. Muscle strength of dominant and non-dominant hand was assessed by standard handgrip dynamometer. Bone quality of distal radius was assessed with HR-pQCT and bone mechanical properties (stiffness, failure load and apparent modulus) were evaluated with finite element analysis (FEA). Maturity was assessed by self-reported Tanner Staging. Partial correlation for adjustment for age, height and weight was used for statistical analysis.

RESULT SECTION: In girls, there was significant correlation between muscle strength and total, cortical and trabecular area of distal radius (R ranged from 0.13 to 0.33). In addition, muscle strength was positively correlated with trabecular thickness (Tb.Th) and negatively correlated with structure model index (SMI) (R = 0.41 and -0.49 respectively) in Tanner 1 and 2 girls indicating that the higher muscle strength was associated with better trabecular bone structure in young girls. In boys, regardless of their maturity, muscle strength were all positively correlated with cortical area, cortical thickness, vBMD in both cortical and trabecular compartment, trabecular bone volume fraction (BV/TV) and Tb.Th (R ranged from 0.17 to 0.33) and negatively correlated with SMI (R=-0.25). Interestingly, unlike girls, in the early pubertal stage (Tanner 1 and 2), muscle strength did not correlate with any vBMD and trabecular
micro-architecture.

In addition, muscle strength was positively correlated with stiffness, failure load and muscle strength in both genders (R ranged from 0.23 to 0.42).

DISCUSSION: Our result indicated that bone morphometry parameters and bone mechanical properties were well correlated with handgrip muscle strength in both genders. Besides, positive correlation between muscle strength and vBMD and trabecular micro-architectural parameters was found in boys. Further studies are warranted investigating the role of handgrip dynamometer for predicting bone quality and bone strength in clinical practice.

SIGNIFICANCE: This is the first study to investigate the correlation between the bone quality and muscle strength in Chinese adolescents. This association is not the same between boys and girls, which might indicate that sexual dimorphism could modulate the mechanism and temporal development of bone-muscle crosstalk during the peri-pubertal growth period.

ACKNOWLEDGEMENT: This study was supported by Research Grants Council of the Hong Kong S.A.R., China (Project no: 468809 and 468411).
著者Ka Yee Cheuk, Vivian W.Y. Hung, Wayne Y.W. Lee, Bobby K.W. Ng, Jack C.Y. Cheng, Tsz Ping Lam
會議名稱Orthopaedic Research Society (ORS) 2017 Annual Meeting
會議開始日19.03.2017
會議完結日22.03.2017
會議地點San Diego, California, USA
會議國家/地區美國
出版年份2017
語言英式英語

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