Unlocking Delivery Strategies for mRNA Therapeutics
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AbstractmRNA emerged as an attractive therapy modality with the development of mRNA structure engineering techniques and delivery platforms. mRNA therapeutics, applied for vaccine therapy, protein replacement therapy, and chimeric antigen receptor (CAR) T cell-based therapy, has shown huge potential in treating a wide range of diseases, such as cancer and rare genetic diseases, with successful and exciting preclinical and clinical progress. In mRNA therapeutics, a potent delivery system is key to the success of its application for disease treatment. Herein, different types of mRNA delivery strategies, including nanoparticles produced from lipid or polymer materials, virus-based platforms, and exosome-based platforms, are mainly focused.
All Author(s) ListZhiyuan LUO, Yangchao CHEN
Journal nameRecent Patents on Anti-Cancer Drug Discovery
Volume Number19
Issue Number2
PublisherBentham Science Publishers
Pages126 - 129
LanguagesEnglish-United Kingdom
KeywordsmRNA delivery, mRNA therapeutics, nucleic acid delivery, gene therapy, delivery system, nanoparticle

Last updated on 2024-10-01 at 14:16