Magnesium containing hybrid fixation system promotes the healing of long bone fractures: a large animal study
Refereed conference paper presented and published in conference proceedings
CUHK Authors
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AbstractIntroduction: Biodegradable magnesium (Mg) is beneficial for fracture healing. However, its applications mainly limited to non-weight-bearing sites as these biometals usually lose their mechanical strength at early stage. We innovatively designed Mg-containing hybrid intramedullary nail (IMN) to maintain the mechanical strength while make good use of the biological effects of Mg. Here we tested the feasibility of our Mg-IMN in the fixation of long bone fracture established in goats, which is essential for broadening clinical applications.
Methods: A total of 36 skeletally mature Chinese mountain goats were divided into IMN group and Mg-IMN group. Osteotomy was conducted at the tibial mid-shaft and the fracture models were fixed with either Ti-based IMN or Mg-IMN.
Results: No implant failure was found during implementation. X-ray and computed tomography results suggested that Mg-IMN group presented with significantly larger callus at early stage of fracture healing, and enhanced mineralisation and remodelling at late stage, as compared to IMN group. Haematoxylin and eosin and Stevenel Blue-Van Gieson-Alizarin Red staining show more callus formation at week 6 and more regular lamellar bone at week 12 in Mg-IMN group than IMN group. Calcein/xylenol double labelling suggest accelerated new-bone formation in the Mg-IMN group at week 6 and accelerated the formation of mature lamellar bone tissue at week 12.
Discussion and Conclusion: To our knowledge, this is the first successful attempt to apply the Mg-IMN for long bone fracture established in large animals. Mg-IMN shows superior outcomes in terms of bone formation as well as remodelling than conventional IMN, highlighting the great translational merit.
Methods: A total of 36 skeletally mature Chinese mountain goats were divided into IMN group and Mg-IMN group. Osteotomy was conducted at the tibial mid-shaft and the fracture models were fixed with either Ti-based IMN or Mg-IMN.
Results: No implant failure was found during implementation. X-ray and computed tomography results suggested that Mg-IMN group presented with significantly larger callus at early stage of fracture healing, and enhanced mineralisation and remodelling at late stage, as compared to IMN group. Haematoxylin and eosin and Stevenel Blue-Van Gieson-Alizarin Red staining show more callus formation at week 6 and more regular lamellar bone at week 12 in Mg-IMN group than IMN group. Calcein/xylenol double labelling suggest accelerated new-bone formation in the Mg-IMN group at week 6 and accelerated the formation of mature lamellar bone tissue at week 12.
Discussion and Conclusion: To our knowledge, this is the first successful attempt to apply the Mg-IMN for long bone fracture established in large animals. Mg-IMN shows superior outcomes in terms of bone formation as well as remodelling than conventional IMN, highlighting the great translational merit.
All Author(s) ListYuantao Zhang, Arthur On Fai Woo, Lizhen Zheng, Michael Tim-yun Ong, Ning Tang, Ronald Man-yeung Wong, Wenxue Tong, Dick Ho Kiu Chow, Jiankun Xu, Ling Qin
Name of ConferenceThe 42nd Annual Congress of The Hong Kong Orthopaedic Association
Start Date of Conference05/11/2022
End Date of Conference06/11/2022
Place of ConferenceHong Kong
Country/Region of ConferenceHong Kong
Year2022
Month11
PublisherHong Kong Academy of Medicine Press
Place of PublicationHong Kong
Article numberAP06
Pages26 - 26
LanguagesEnglish-United States
