Regulation of mitochondrial dynamic equilibrium by physical exercise in sarcopenia: A systematic review
Publication in refereed journal
香港中文大學研究人員
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摘要Background: Sarcopenia is a hallmark of the ageing process, which is characterized by the decline in muscle mass and strength. Growing evidence indicates that mitochondria dysfunction play core roles in this process. Mean-while, physical exercise is regarded as one of the efficiency therapies to attenuate sarcopenia via regulating mitochondrial function during ageing. However, the specific mechanisms among exercise, mitochondrial function and sarcopenia are still unclear. The aim of this systematic review is to delineate the effects of physical exercise on mitochondria during ageing in order to explore potential target for rescuing sarcopenia.Methods: A systematic literature search was performed in PubMed, Embase and Web of Science. Information was extracted from the included studies for review.Results: In this review, 16 pre-clinical studies were included and 105 clinical studies that were not mechanistic research were excluded. 16 pre-clinical studies provided evidence that physical exercise could affect mitochon-drial quality control to attenuate sarcopenia. Most of the included studies described the important role of mitochondrial dynamic equilibrium in sarcopenia and showed that effective physical exercise could influence mitochondrial biogenesis, fusion, fission and mitophagy to attenuate sarcopenia in aged animal. Conclusions: This systematic review provides an up-to-date sequential overview and highlights the link in the potential mitochondria-related target and physical exercise in aged animal. Translation of this article: Currently, there is no standard treatment method for sarcopenia. This systematic review revealed the underlying mechanisms for how physical exercise improved muscle performance via regulating mitochondrial dynamic equilibrium, which could provide scientific support for using exercise as a timely inter-vention for sarcopenia. Additionally, this systematic review allows a better understanding of mitochondrial dy-namic equilibrium and exercise for future development of new therapeutic interventions to attenuate sarcopenia.
出版社接受日期17.06.2022
著者Long YF, Chow SKH, Cui C, Wong RMY, Qin L, Law SW, Cheung WH
期刊名稱Journal of Orthopaedic Translation
出版年份2022
月份7
卷號35
出版社ELSEVIER
頁次37 - 52
國際標準期刊號2214-031X
語言英式英語
關鍵詞Sarcopenia, Skeletal muscle, Mitochondria, Apoptosis, Physical exercise
Web of Science 學科類別Orthopedics;Orthopedics
