Regulation of mitochondrial dynamic equilibrium by physical exercise in sarcopenia: A systematic review
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AbstractBackground: Sarcopenia is a hallmark of the ageing process, which is characterized by the decline in muscle mass and strength. Growing evidence indicates that mitochondria dysfunction play core roles in this process. Mean-while, physical exercise is regarded as one of the efficiency therapies to attenuate sarcopenia via regulating mitochondrial function during ageing. However, the specific mechanisms among exercise, mitochondrial function and sarcopenia are still unclear. The aim of this systematic review is to delineate the effects of physical exercise on mitochondria during ageing in order to explore potential target for rescuing sarcopenia.Methods: A systematic literature search was performed in PubMed, Embase and Web of Science. Information was extracted from the included studies for review.Results: In this review, 16 pre-clinical studies were included and 105 clinical studies that were not mechanistic research were excluded. 16 pre-clinical studies provided evidence that physical exercise could affect mitochon-drial quality control to attenuate sarcopenia. Most of the included studies described the important role of mitochondrial dynamic equilibrium in sarcopenia and showed that effective physical exercise could influence mitochondrial biogenesis, fusion, fission and mitophagy to attenuate sarcopenia in aged animal. Conclusions: This systematic review provides an up-to-date sequential overview and highlights the link in the potential mitochondria-related target and physical exercise in aged animal. Translation of this article: Currently, there is no standard treatment method for sarcopenia. This systematic review revealed the underlying mechanisms for how physical exercise improved muscle performance via regulating mitochondrial dynamic equilibrium, which could provide scientific support for using exercise as a timely inter-vention for sarcopenia. Additionally, this systematic review allows a better understanding of mitochondrial dy-namic equilibrium and exercise for future development of new therapeutic interventions to attenuate sarcopenia.
Acceptance Date17/06/2022
All Author(s) ListLong YF, Chow SKH, Cui C, Wong RMY, Qin L, Law SW, Cheung WH
Journal nameJournal of Orthopaedic Translation
Year2022
Month7
Volume Number35
PublisherELSEVIER
Pages37 - 52
ISSN2214-031X
LanguagesEnglish-United Kingdom
KeywordsSarcopenia, Skeletal muscle, Mitochondria, Apoptosis, Physical exercise
Web of Science Subject CategoriesOrthopedics;Orthopedics

Last updated on 2024-20-08 at 00:30