Cartilage organoids for cartilage development and cartilage-associated disease modeling
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Cartilage organoids have emerged as powerful modelling technology for recapitulation of joint embryonic events, and cartilage regeneration, as well as pathophysiology of cartilage-associated diseases. Recent breakthroughs have uncovered “mini-joint” models comprising of multicellular components and extracellular matrices of joint cartilage for development of novel disease-modifying strategies for personalized therapeutics of cartilage-associated diseases. Here, we hypothesized that LGR5-expressing embryonic joint chondroprogenitor cells are ideal stem cells for the generation of cartilage organoids as “mini-joints” ex vivo “in a dish” for embryonic joint development, cartilage repair, and cartilage-associated disease modelling as essential research models of drug screening for further personalized regenerative therapy. The pilot research data suggested that LGR5-GFP-expressing embryonic joint progenitor cells are promising for generation of cartilage organoids through gel embedding method, which may exert various preclinical and clinical applications for realization of personalized regenerative therapy in the future.
著者Weiping Lin, Min Wang, Liangliang Xu, Micky Tortorella, Gang Li
期刊名稱Frontiers in Cell and Developmental Biology
出版年份2023
月份1
卷號11
出版社Frontiers Media
文章號碼1125405
電子國際標準期刊號2296-634X
語言美式英語

上次更新時間 2024-09-04 於 00:39