Cartilage organoids for cartilage development and cartilage-associated disease modeling
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AbstractCartilage organoids have emerged as powerful modelling technology for recapitulation of joint embryonic events, and cartilage regeneration, as well as pathophysiology of cartilage-associated diseases. Recent breakthroughs have uncovered “mini-joint” models comprising of multicellular components and extracellular matrices of joint cartilage for development of novel disease-modifying strategies for personalized therapeutics of cartilage-associated diseases. Here, we hypothesized that LGR5-expressing embryonic joint chondroprogenitor cells are ideal stem cells for the generation of cartilage organoids as “mini-joints” ex vivo “in a dish” for embryonic joint development, cartilage repair, and cartilage-associated disease modelling as essential research models of drug screening for further personalized regenerative therapy. The pilot research data suggested that LGR5-GFP-expressing embryonic joint progenitor cells are promising for generation of cartilage organoids through gel embedding method, which may exert various preclinical and clinical applications for realization of personalized regenerative therapy in the future.
All Author(s) ListWeiping Lin, Min Wang, Liangliang Xu, Micky Tortorella, Gang Li
Journal nameFrontiers in Cell and Developmental Biology
Year2023
Month1
Volume Number11
PublisherFrontiers Media
Article number1125405
eISSN2296-634X
LanguagesEnglish-United States
