Association of human-leukocyte-antigen class I (B*0703) and class II (DRB1*0301) genotypes with susceptibility and resistance to the development of severe acute respiratory syndrome
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摘要Severe acute respiratory syndrome (SARS) is a public health concern worldwide. By studying the human leukocyte antigen (HLA) types A, B, DR, and DQ alleles in 90 Chinese patients with serologically confirmed SARS infections, we identified a strong association between HLA-B*0703 (OR, 4.08; 95% CI, 2.03-8.18; P = .00072 [Bonferroni-corrected P value, Pc<.0022]) and -DRB1*0301 (OR, 0.06; 95%, 0.01-0.47; P = .00008 [after Bonferroni correction, P < .0042]) and the development of SARS. Moreover, the frequency of B*0703 and B60 coinheritance (9.6%; 95% CI, 4.6%-19.0%) in our SARS group was significantly higher (P = 3 × 10-9) than that expected in the general population (0.4%). These genetic data will critically affect both the study of the pathogenesis of SARS and the design of vaccination programs.
著者Ng M.H.L., Lau K.-M., Li L., Cheng S.-H., Chan W.Y., Hui P.K., Zee B., Leung C.-B., Sung J.J.Y.
期刊名稱Journal of Infectious Diseases
出版年份2004
月份8
日期1
卷號190
期次3
出版社University of Chicago Press
出版地United States
頁次515 - 518
國際標準期刊號0022-1899
電子國際標準期刊號1537-6613
語言英式英語

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