Effect of cranial irradiation on pituitary size in patients cured of acute lymphoblastic leukaemia: Retrospective study
Publication in refereed journal


摘要Objective: To evaluate the pituitary glands of patients previously treated for acute lymphoblastic leukaemia with cranial irradiation. Patients and methods: Thirty nine patients who were cured of acute lymphoblastic leukaemia and who were regularly followed up from 1979 to 1992 were recruited. Sagittal T1-weighted magnetic resonance imaging of the pituitary gland was performed in a 1.5-T magnetic resonance machine. Sixteen age- and sex-matched patients who had been treated during childhood for solid extracranial neoplasms with systemic chemotherapy, but not intracranial irradiation, were recruited as controls. Results: The height of the adenohypophysis was significantly smaller in patients who had had acute lymphoblastic leukaemia (mean, 3.9 mm; standard deviation, 1.2 mm) than in control patients (mean, 5.3 mm; standard deviation, 1.1 mm) [p<0.001]. For both patients who had had acute lymphoblastic leukaemia and for controls, there was no significant correlation between pituitary height and age at diagnosis or age at the time of the study. In the group of patients who had had acute lymphoblastic leukaemia, the pituitary was shorter in those treated with more than 18 Gy of radiation (mean, 3.0 mm; standard deviation, 1.3 mm) than in those treated with exactly 18 Gy (mean, 4.1 mm; standard deviation, 1.1 mm) [p=0.037]. Conclusion: Children cured of acute lymphoblastic leukaemia with previous cranial irradiation show a significant reduction in the height of the adenohypophysis. The effect on the size of the pituitary gland appears greater with a higher radiation dose.
著者Shing K.K., Roebuck D., Yuen M.P., Chik K.W., Li C.K., Chan Y.L.
期刊名稱Journal- Hong Kong College of Radiologists
出版社Scientific Communications International Ltd.
出版地Hong Kong
頁次195 - 198
關鍵詞Cranial irradiation, Leukemia, lymphocytic, acute/radiotherapy, Pituitary gland/radiation effects

上次更新時間 2020-04-09 於 01:36