New-onset diabetes and antihypertensive drugs: Implications for renin-angiotensin system blockade
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AbstractHypertensive patients are frequently overweight with impaired glucose tolerance. Thiazide diuretics and betablockers are commonly used as first line anti-hypertensive drugs. While effective in blood pressure lowering, these drugs have the propensity to exacerbate glucose intolerance in overweight individuals with insulin resistance resulting in new-onset diabetes. In contrast, drugs that block the renin-angiotensin system improve glucose metabolism and reduce new-onset diabetes. This article reviews evidence from recent clinical trial and discusses the potential mechanisms whereby blockade of the renin-angiotensin system improves glucose metabolism.
All Author(s) ListChan N.N., Kong A.P.S., Chan J.C.N.
Journal nameHong Kong Practitioner
Volume Number26
Issue Number12
PublisherHong Kong College of Family Physicians
Place of PublicationHong Kong
Pages515 - 519
LanguagesEnglish-United Kingdom

Last updated on 2020-02-09 at 00:09