Vitamin D receptor start codon polymorphism (Fok I) and bone mineral density in Chinese men and women
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AbstractThe relationship between Fok I polymorphism of the vitamin D receptor start codon, bone mineral density (BMD) and vertebral fractures was studied in 684 Chinese men and women. A significant trend was observed only in Chinese women aged 70-79 years. The mean BMD at the total body was 0.85 ± 0.01 g/cm2, 0.82 ± 0.0 1 g/cm2 and 0.84 ± 0.01 g/cm2 for elderly women of the FF, Ff and ff genotypes respectively (p = 0.06 by ANOVA). Similar but statistically non-significant trends were observed at the hip and spine. However, no association between BMD and the Fok I genotype was observed in younger women (aged 50-59 years) and elderly men (aged 70-79 years). In all study groups, there was no effect of an interaction between Fok I polymorphism and calcium intake on BMD (p > 0.05 for the interaction effects by two-way ANOVA). No significant association was observed between Fok I polymorphism and vertebral fracture in elderly men or women (p > 0.05 by the chi-square test). We conclude that the Fok I polymorphism may have a weak effect on the BMD of elderly Chinese women.
All Author(s) ListLau E.M.C., Lam V., Li M., Ho K., Woo J.
Journal nameOsteoporosis International
Volume Number13
Issue Number3
PublisherSpringer Verlag
Place of PublicationGermany
Pages218 - 221
LanguagesEnglish-United Kingdom
KeywordsBone mineral density, Chinese, Fok I polymorphism of the vitamin D gene, Vertebral fracture

Last updated on 2020-22-11 at 02:00