Application of fetal DNA in maternal plasma for noninvasive prenatal diagnosis
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AbstractPrenatal diagnosis of fetal genetic conditions is a standard part of modern obstetric care. Many of the current methods rely on invasive methods and are associated with an inherent risk of fetal loss. Consequently, there has been a long-term goal for development of noninvasive prenatal diagnostic methods. In 1997, the presence of fetal DNA in maternal plasma was first discovered through the detection of Y-chromosome-specific sequences in the plasma of women conceived with male fetuses. This discovery has opened up new possibilities in the development of noninvasive prenatal diagnostic methods through a source of fetal genetic material that could be conveniently accessible simply through the collection of a maternal peripheral blood sample. To date, there have been numerous reported applications, including fetal RhD genotyping, prenatal diagnosis of sex-linked disorders, paternally inherited genetic diseases and some pregnancy-associated conditions, including preeclampsia. More recently, there have been significant new developments with expanding number of potential applications.
All Author(s) ListChiu R.W.K., Lo Y.M.D.
Journal nameExpert Review of Anticancer Therapy
Year2002
Month6
Day29
Volume Number2
Issue Number1
PublisherFuture Drugs Ltd.
Place of PublicationUnited Kingdom
Pages32 - 40
ISSN1473-7140
eISSN1744-8328
LanguagesEnglish-United Kingdom
KeywordsDiagnosis, Noninvasive, Plasma DNA, Prenatal, Quantitative PCR, Real-time

Last updated on 2020-01-08 at 01:52