Clinical Use of Mood Stabilizers With Antidepressants in Asia: Report From the Research on Asian Psychotropic Prescription Patterns for Antidepressants (REAP-AD) Projects in 2004 and 2013
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AbstractObjective As most reports concerning treatment with combinations of mood stabilizer (MS) with antidepressant (AD) drugs are based in the West, we surveyed characteristics of such cotreatment in 42 sites caring for the mentally ill in 10 Asian countries.Methods This cross-sectional, pharmacoepidemiologic study used 2004 and 2013 data from the REAP-AD (Research Study on Asian Psychotropic Prescription Patterns for Antidepressants) to evaluate the rates and doses of MSs given with ADs and associated factors in 4164 psychiatric patients, using standard bivariate methods followed by multivariable logistic regression modeling.Results Use of MS + AD increased by 104% (5.5% to 11.2%) between 2004 and 2013 and was much more associated with diagnosis of bipolar disorder than major depression or anxiety disorder, as well as with hospitalization > outpatient care, psychiatric > general-medical programs, and young age (all P < 0.001), but not with country, sex, or AD dose.Conclusions The findings provide a broad picture of contemporary use of MSs with ADs in Asia, support predictions that such treatment increased in recent years, and was associated with diagnosis of bipolar disorder, treatment in inpatient and psychiatric settings, and younger age.
All Author(s) ListRajaratnam K, Xiang YT, Tripathi A, Chiu HFK, Si TM, Chee KY, Avasthi A, Grover S, Chong MY, Kuga H, Kanba S, He YL, Lee MS, Yang SY, Udomratn P, Kallivayalil RA, Tanra AJ, Maramis MM, Shen WW, Sartorius N, Kua EH, Tan CH, Mahendran R, Shinfuku N, Sum MY, Baldessarini RJ, Sim K
Journal nameJournal of Clinical Psychopharmacology
Volume Number37
Issue Number2
Pages255 - 259
LanguagesEnglish-United Kingdom
Keywordsantidepressant, anxiety, bipolar disorder, major depression, mood stabilizer
Web of Science Subject CategoriesPharmacology & Pharmacy;Psychiatry;Pharmacology & Pharmacy;Psychiatry

Last updated on 2020-28-09 at 00:42