Adjunctive antidepressant use in schizophrenia in China: A national survey (2002–2012)
Publication in refereed journal

香港中文大學研究人員

引用次數
替代計量分析
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其它資訊
摘要Objective

This study examined the pattern of adjunctive antidepressant use in schizophrenia patients and its demographic and clinical correlates in a nationwide survey in China.

Methods

Fourteen thousand and thirteen patients in 45 Chinese psychiatric hospitals or centers were interviewed (4,486 in 2002, 5,288 in 2006, and 4,239 in 2012). Patients' sociodemographic and clinical characteristics were recorded using a standardized protocol and data collection procedure. Chi-square test, independent-samples t test, Mann–Whitney U test, and multiple logistic regression analysis were used in data analyses.

Results

Antidepressant use was found in 5.2% of the study population with 4.6% in 2002, 4.3% in 2006, and 6.9% in 2012, respectively. A significant increase in use from 2006 to 2012 was found (p < .001). Multiple logistic regression analyses in the whole population revealed that patients receiving adjunctive antidepressants were more likely to be outpatients in tertiary referral centers (level-III hospitals) and who had an earlier age of onset, less severe global illness, but more depressive symptoms. They were less likely to receive first-generation antipsychotics but more likely to receive benzodiazepines (R2 = 0.255, p < .001).

Conclusions

Despite an increasing trend, the frequency of antidepressant use in schizophrenia in China was considerably lower than in Western countries. The benefits and risks associated with concomitant use of antidepressants in schizophrenia need to be studied further.
著者Qian Li, Yun-Ai Su, Yu-Tao Xiang, Liang Shu, Xin Yu, Gabor S. Ungvari, Chee H. Ng, Helen F.K. Chiu, Yu-Ping Ning,
Gao-Hua Wang, Ke-Rang Zhang, Tao Li, Li-Zhong Sun, Jian-Guo Shi, Xian-Sheng Chen, Qi-Yi Mei, Ke-Qing Li, Tian-Mei Si
期刊名稱Human Psychopharmacology: Clinical and Experimental
出版年份2017
月份1
卷號32
期次1
出版社Wiley
頁次e2571
國際標準期刊號0885-6222
電子國際標準期刊號1099-1077
語言英式英語
關鍵詞antidepressants, China, schizophrenia
Web of Science 學科類別Clinical Neurology;Pharmacology & Pharmacy;Psychiatry;Psychology;Neurosciences & Neurology;Pharmacology & Pharmacy;Psychiatry;Psychology

上次更新時間 2020-28-06 於 02:22