Association between sleep duration and cardiac structure in youths at risk for metabolic syndrome
Publication in refereed journal


Full Text

Times Cited
Altmetrics Information
.

Other information
AbstractThe evidence for a link between sleep duration and cardiovascular risk is accumulating in youths, but no study has yet investigated the relationship between sleep duration and change of cardiac structure. In this study, we recruited 559 youths aged 14-28 years from the cohort of Beijing Child and Adolescent Metabolic Syndrome Study. Questionnaire, color Doppler echocardiography, oral glucose tolerance test and blood biomarkers analyses were performed. We found that sleep duration was negatively correlated with body mass index, waist circumstance, and HbA1c (all P < 0.05), but not with adiponectin and leptin. Meanwhile, participants with shorter sleep duration (<= 7 h) had larger interventricular septal diastolic thickness, left ventricular (LV) end-diastolic diameter, LV posterior wall thickness, LV mass (LVM), and LV mass index (LVMI), compared to participants in 7-9 h/night or > 9 h/night group. Findings remained significant after adjustment for the major confounding factors (P < 0.05). Multivariate regression modeling revealed that each additional hour of sleep was associated with smaller LVM (beta: -3.483, P < 0.0001) and LVMI (beta: -0.815, P < 0.0001). Our findings suggest that short sleep has a possible direct effect on cardiac remodeling, occurring already at young ages.
All Author(s) ListFeng D, Zhang JH, Fu JL, Wu H, Wang YH, Li LJ, Zhao YL, Li M, Gao S
Journal nameScientific Reports
Year2016
Month12
Volume Number6
PublisherNATURE PUBLISHING GROUP
Pages39017
ISSN2045-2322
eISSN2045-2322
LanguagesEnglish-United Kingdom
Web of Science Subject CategoriesMultidisciplinary Sciences;Science & Technology - Other Topics

Last updated on 2020-01-12 at 01:20