Acute effects of a surgical menopause on serum concentrations of lipoprotein(a)
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摘要Objective: The aim of this study was to investigate acute changes in serum concentra-tions of lipoprotein(a) and other atherogenic lipids and lipoproteins after a surgical menopause. Methods: A total of 100 premenopausal Chinese women who were booked for hysterectomy for benign gynecological disorders were recruited. They study group comprised 40 subjects undergoing hysterectomy as well as bilateral oophorectomy. The control group consisted of 60 subjects undergoing hysterectomy with conservation of the ovaries. Complete data were available from 30 of the 40 subjects in the study group and from 44 of the 60 controls. Serum concentrations of lipoprotein(a) and other atherogenic lipids and lipoproteins were measured before surgery and these measurements were repeated 3 days, 8 weeks and 6 months postoperatively. Those study patients who received hormone replacement therapy and control patients who became menopausal, according to biochemical criteria, during the study period were excluded from analysis. Results: Three days after surgery, there was a significant increase in the mean lipoprotein(a) concentration in the control group from 19.1 to 23.0 mg/dl (p < 0.01), but there was no significant change in the study group. There were no significant changes from baseline in the mean lipoprotein(a) concentration in either group 8 weeks or 6 months after surgery. There was a significant increase in the mean concentration of total cholesterol in the study group 8 weeks after surgery from 5.08 to 5.45 mmol/l (p < 0.01), in low density lipoprotein cholesterol from 3.22 to 3.49 mmol/1 (p < 0.01), and in apolipoprotein B from 95.6 to 103.0 mg/dl (p < 0.05). However, the mean concentrations 6 months after surgery were not significantly different from baseline levels. The mean concentrations of high density lipoprotein cholesterol, apolipoprotein A-1 and triglycerides also did not differ significantly from baseline in the study group, either 8 weeks or 6 months after surgery. Conclusions: These results suggest that any increase in concentrations of lipoprotein(a), and other atherogenic lipids and lipoproteins which occur after the menopause, develops relatively slowly. The changes in concentrations which occurred within 8 weeks of surgery were probably an acute-phase reaction after surgery rather than a response to a decreasing estradiol concentration.
著者Cheung L.P., Pang M.W., Lam C.W.K., Tomlinson B., Chung T.K.H., Haines C.J.
期刊名稱Climacteric
出版年份1998
月份3
日期1
卷號1
期次1
出版社Parthenon Publishing Group
出版地United Kingdom
頁次33 - 41
國際標準期刊號1369-7137
電子國際標準期刊號1473-0804
語言英式英語
關鍵詞Lipids, Lipoprotein(a), Surgical menopause

上次更新時間 2020-25-10 於 01:25