Nucleophosmin Interacts with PIN2/TERF1-interacting Telomerase Inhibitor 1 (PinX1) and Attenuates the PinX1 Inhibition on Telomerase Activity.
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摘要Telomerase activation and telomere maintenance are critical for cellular immortalization and transformation. PIN2/TERF1-interacting telomerase inhibitor 1 (PinX1) is a telomerase regulator and the aberrant expression of PinX1 causes telomere shortening. Identifying PinX1-interacting proteins is important for understanding telomere maintenance. We found that PinX1 directly interacts with nucleophosmin (NPM), a protein that has been shown to positively correlate with telomerase activity. We further showed that PinX1 acts as a linker in the association between NPM and hTERT, the catalytic subunit of telomerase. Additionally, the recruitment of NPM by PinX1 to the telomerase complex could partially attenuate the PinX1-mediated inhibition on telomerase activity. Taken together, our data reveal a novel mechanism that regulates telomerase activation through the interaction between NPM, PinX1 and the telomerase complex.
著者Cheung DH, Ho ST, Lau KF, Jin R, Wang YN, Kung HF, Huang JJ, Shaw PC
期刊名稱Scientific Reports
詳細描述Article number: 43650
出版年份2017
月份3
日期3
卷號7
出版社Nature publish group
國際標準期刊號2045-2322
電子國際標準期刊號2045-2322
語言英式英語
關鍵詞Proteins, Telomeres, Tumour-suppressor proteins

上次更新時間 2020-08-07 於 05:24