Towards in silico prognosis using big data
Refereed conference paper presented and published in conference proceedings


摘要Clinical diagnosis and prognosis usually rely on few or even single measurements despite clinical big data being available. This limits the exploration of complex diseases such as adolescent idiopathic scoliosis (AIS) where the associated low bone mass remains unexplained. Observed low physical activity and increased RANKL/OPG, however, both indicate a mechanobiological cause. To deepen disease understanding, we propose an in silico prognosis approach using clinical big data, i.e. medical images, serum markers, questionnaires and live style data from mobile monitoring devices and explore the role of inadequate physical activity in a first AIS prototype. It employs a cellular automaton (CA) to represent the medical image, micro-finite element analysis to calculate loading, and a Boolean network to integrate the other biomarkers. Medical images of the distal tibia, physical activity scores, and vitamin D and PTH levels were integrated as measured clinically while the time development of bone density and RANKL/OPG was observed. Simulation of an AIS patient with normal physical activity and patient-specific vitamin D and PTH levels showed minor changes in bone density whereas the simulation of the same AIS patient but with reduced physical activity led to low density. Both showed unchanged RANKL/OPG and considerable cortical resorption. We conclude that our integrative in silico approach allows to account for a variety of clinical big data to study complex diseases.
著者Ohs, N., Keller, F., Blank, O. , Lee, W. Y. W. , Cheng, J. C. Y. , Arbenz. P., Muller, R., Christen, P.
會議名稱BMT 2016 "Dreiländertagung" Swiss, Austrian and German Societies of Biomedical Engineering
會議地點Basel, Switzerland
會議論文集題名Current Directions in Biomedical Engineering
出版社De Gruyter
頁次57 - 60
關鍵詞adolescent idiopathic scoliosis, Boolean network, cellular automaton, clinical big data, micro-finite element analysis.

上次更新時間 2021-17-02 於 19:33