The Evaluation of Corneal Fragility After UVA/Riboflavin Crosslinking
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AbstractPurpose:To evaluate the fragility of cornea after UVA/riboflavin crosslinking (CXL).Methods:Sixty New Zealand rabbits received UVA/riboflavin crosslinking treatment (wavelength 365 nm, irradiance 3.0 mW/cm(2), and total dose 5.4 J/cm(2)) on right eyes. Animals were sacrificed before and immediately after treatment (day 0), day 1, 3, 7, and 28 after treatment. A 4x10 mm corneal strip for biomechanical evaluation was harvested after sacrifice. The corneal fragility was evaluated by measurement of elongation rate, whereby the elongation rate equals elongation length/baseline length.Results:The Youngs modulus and maximal stress were 1.410.51 MPa and 5.56 +/- 1.84 MPa before CXL, and increased to 2.31 +/- 0.68 MPa (P=0.008) and 9.25 +/- 2.74 MPa (P=0.04), respectively, on day 0, then maintained a stable level within a 28 days follow-up. The elongation rate was 62.04 +/- 9.34% before CXL and decreased to 48.95%+/- 8.24% (P=0.02) on day 0, then maintained a stable level within a 28 days follow-up.Conclusions:This study showed an increase in the corneal fragility after UVA/riboflavin crosslinking along with an increase in the corneal stiffness. A long-term follow-up should be taken to evaluate the potential deleterious effect of the increasing corneal fragility after UVA/riboflavin crosslinking.
All Author(s) ListLi ZW, Wang YM, Xu YY, Jhanji V, Zhang CX, Mu GY
Journal nameEye and Contact Lens
Volume Number43
Issue Number2
Pages100 - 102
LanguagesEnglish-United Kingdom
KeywordsUVA, Crosslinking, Cornea, Fragility
Web of Science Subject CategoriesOphthalmology;Ophthalmology

Last updated on 2021-17-01 at 01:37