Change in flash visual evoked potentials in New Zealand albino rabbits after sub-tenon's anesthesia
Publication in refereed journal

Times Cited
Web of Science3WOS source URL (as at 21/01/2021) Click here for the latest count
Altmetrics Information

Other information
AbstractContext: The occurrence of amaurosis during ophthalmic anesthesia is well known. The reason for this manifestation has not been studied.Purpose: To investigate the effect of sub-tenon's anesthesia on visual conduction in rabbit eyes.Methods: Fifteen right eyes of 15 New Zealand albino rabbits were included. 2% lidocaine hydrochloride and 0.75% bupivacaine hydrochloride (1ml, 1:1 mixture) was injected in the sub-tenon's space of 8 eyes while the control group (n=7) was injected with 1ml physiological saline. Flash visual evoked potentials (FVEP) were performed with Roland reti-scan system before and, 5min, 15min, and 5 days after injection. The natural pupillary diameter and minimal pupillary diameter with light reflex were recorded.Results: In the anesthesia group, N1 latency, P1 latency, and P1 amplitude were 17.131.13ms, 28.251.83ms, 13.45 +/- 4.36v respectively before injection; 21.75 +/- 3.06ms, 29.63 +/- 2.67ms, 7.24 +/- 4.64v at 5min after injection; 22.25 +/- 1.39ms, 29.50 +/- 2.51ms, 7.54 +/- 4.47v at 15min after injection, and, 17.75 +/- 0.71ms, 28.13 +/- 2.42ms, 13.17 +/- 4.08v 5 days after injection. When compared with baseline, N1 latency at 5min and 15min after injection showed prolongation (p=0.019 and p=0.001, respectively). Likewise, P1 amplitude decreased at 5min and 15min after injection (p<0.001, p<0.001, respectively). Both N1 latency and P1 amplitude recovered 5 days after the injection. Pupillary light reflex (PLR) constriction amplitude was 35.42% and 0.00% before and at 5min after injection (p=0.012). After 5 days it recovered to 33.33%. The FVEP and PLR constriction amplitude did not change significantly after injection in the control group.Discussion: Sub-tenon's anesthesia was associated with changes in the FVEP and pupullary light reflex in rabbit eyes in our study.Conclusions: The data from this study suggested that sub-tenon's anesthesia could reversibly block visual conduction in rabbit's eyes.
All Author(s) ListWu XF, Jhanji V, Chen HY, Lin HJ, Zhang GH, Brelen M, Chen WQ
Journal nameCutaneous and Ocular Toxicology
Volume Number36
Issue Number2
Pages118 - 124
LanguagesEnglish-United Kingdom
KeywordsOphthalmic anesthesia,sub-tenon's anesthesia,visual potential
Web of Science Subject CategoriesOphthalmology;Toxicology;Ophthalmology;Toxicology

Last updated on 2021-22-01 at 01:30