Circulating MicroRNAs in Delayed Cerebral Infarction After Aneurysmal Subarachnoid Hemorrhage
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AbstractBackground Delayed cerebral infarction (DCI) is a major cause of morbidities after aneurysmal subarachnoid hemorrhage (SAH) and typically starts at day 4 to 7 after initial hemorrhage. MicroRNAs (miRNAs) play an important role in posttranscriptional gene expression control, and distinctive patterns of circulating miRNA changes have been identified for some diseases. We aimed to investigate miRNAs that characterize SAH patients with DCI compared with those without DCI.

Methods and Results Circulating miRNAs were collected on day 7 after SAH in healthy, SAH‐free controls (n=20), SAH patients with DCI (n=20), and SAH patients without DCI (n=20). We used the LASSO (least absolute shrinkage and selection operator) method of regression analysis to characterize miRNAs associated with SAH patients with DCI compared with those without DCI. In the 28 dysregulated miRNAs associated with DCI and SAH, we found that a combination of 4 miRNAs (miR‐4532, miR‐4463, miR‐1290, and miR‐4793) could differentiate SAH patients with DCI from those without DCI with an area under the curve of 100% (95% CI 1.000–1.000, P<0.001). This 4‐miRNA combination could also distinguish SAH patients with or without DCI from healthy controls with areas under the curve of 99.3% (95% CI 0.977–1.000, P<0.001) and 82.0% (95% CI 0.685–0.955, P<0.001), respectively.

Conclusions We found a 4‐miRNA combination that characterized SAH patients with DCI. The findings could guide future mechanistic study to develop therapeutic targets.
All Author(s) ListLu Gang, Wong Man Sze, Xiong Mark Zhi Qiang, Leung Chi Kwan, Su Xian Wei, Zhou Jing Ye, Poon Wai Sang, Zheng Vera Zhi Yuan, Chan Wai Yee , Wong George Kwok Chu
Journal nameJournal of the American Heart Association
Volume Number6
Issue Number4
LanguagesEnglish-United States
Keywordsbiomarker, delayed cerebral infarction, miRNA, stroke, subarachnoid hemorrhage

Last updated on 2021-14-09 at 00:50