Elevated angiopoietin 2 in aqueous of patients with neovascular age related macular degeneration correlates with disease severity at presentation
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AbstractAngiopoietin 2 (ANG2) is a proangiogenic cytokine which may have an implication in neovascular age related macular degeneration (nAMD). In 24 eyes of 24 subjects presenting with treatment naïve nAMD and 26 eyes of 26 control patients, aqueous humor samples were collected at the time of intervention (intravitreal injection of anti-vascular endothelial growth factor or cataract extraction). Best corrected visual acuity (BCVA) with and central macular thickness (CMT) using optical coherence tomography (OCT) were measured before each injection in the nAMD group. Aqueous cytokine levels were determined by immunoassay using a multiplex array (Quansys Biosciences, Logan, UT). Levels of ANG2 in the aqueous were significantly higher in nAMD patients than those of the control group (p < 0.0001), so were hepatocyte growth factor (HGF), interleukin-8 (IL-8) and tissue inhibitor of metalloproteinase 1 (TIMP 1), all with p < 0.001. ANG2 correlated with worse BCVA (r = 0.44, p-value = 0.027) and greater CMT (r = 0.66, p-value < 0.0001) on optical coherence tomography (OCT). ANG2 is upregulated in patients with nAMD and correlates with severity of disease at presentation.
Acceptance Date17/02/2017
All Author(s) ListDanny S. Ng, Yolanda W. Yip, Malini Bakthavatsalam, Li J. Chen, Tse K. Ng, Timothy Y. Lai, Calvin P. Pang, Mårten E. Brelén
Journal nameScientific Reports
Detailed descriptionArticle number: 45081
Year2017
Month3
Day27
Volume Number7
Pages1 - 6
ISSN2045-2322
eISSN2045-2322
LanguagesEnglish-United States
KeywordsENDOTHELIAL GROWTH-FACTOR, POLYPOIDAL CHOROIDAL VASCULOPATHY, INTRAVITREAL BEVACIZUMAB, ACTIVATES TIE2, HUMOR LEVELS, RANIBIZUMAB, VEGF, AFLIBERCEPT, MEMBRANES, THERAPY

Last updated on 2021-18-02 at 00:05