Elevated angiopoietin 2 in aqueous of patients with neovascular age related macular degeneration correlates with disease severity at presentation
Publication in refereed journal

替代計量分析
.

其它資訊
摘要Angiopoietin 2 (ANG2) is a proangiogenic cytokine which may have an implication in neovascular age related macular degeneration (nAMD). In 24 eyes of 24 subjects presenting with treatment naïve nAMD and 26 eyes of 26 control patients, aqueous humor samples were collected at the time of intervention (intravitreal injection of anti-vascular endothelial growth factor or cataract extraction). Best corrected visual acuity (BCVA) with and central macular thickness (CMT) using optical coherence tomography (OCT) were measured before each injection in the nAMD group. Aqueous cytokine levels were determined by immunoassay using a multiplex array (Quansys Biosciences, Logan, UT). Levels of ANG2 in the aqueous were significantly higher in nAMD patients than those of the control group (p < 0.0001), so were hepatocyte growth factor (HGF), interleukin-8 (IL-8) and tissue inhibitor of metalloproteinase 1 (TIMP 1), all with p < 0.001. ANG2 correlated with worse BCVA (r = 0.44, p-value = 0.027) and greater CMT (r = 0.66, p-value < 0.0001) on optical coherence tomography (OCT). ANG2 is upregulated in patients with nAMD and correlates with severity of disease at presentation.
出版社接受日期17.02.2017
著者Danny S. Ng, Yolanda W. Yip, Malini Bakthavatsalam, Li J. Chen, Tse K. Ng, Timothy Y. Lai, Calvin P. Pang, Mårten E. Brelén
期刊名稱Scientific Reports
詳細描述Article number: 45081
出版年份2017
月份3
日期27
卷號7
頁次1 - 6
國際標準期刊號2045-2322
電子國際標準期刊號2045-2322
語言美式英語
關鍵詞ENDOTHELIAL GROWTH-FACTOR, POLYPOIDAL CHOROIDAL VASCULOPATHY, INTRAVITREAL BEVACIZUMAB, ACTIVATES TIE2, HUMOR LEVELS, RANIBIZUMAB, VEGF, AFLIBERCEPT, MEMBRANES, THERAPY

上次更新時間 2021-17-01 於 01:34