Acupuncture for detoxification in treatment of opioid addiction
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AbstractOpioid is a popular drug of abuse and addiction. We evaluated acupuncture as a non-pharmacological treatment with a focus on managing withdrawal symptoms. Electrical stimulation at a low frequency (2 Hz) accelerates endorphin and encephalin production. High-frequency stimulation (100 Hz) upregulates the dynorphin level that in turn suppresses withdrawal at the spinal level. The effect of 100-Hz electroacupuncture may be associated with brain-derived neurotrophic factor activation at the ventral tegmental area, down-regulation of cAMP response element-binding protein, and enhanced dynorphin synthesis in the spinal cord, periaqueductal grey, and hypothalamus. Clinical trials of acupuncture for the management of different withdrawal symptoms were reviewed. The potential of acupuncture to allay opioid-associated depression and anxiety, and its possible use as an adjuvant treatment were evident. A lack of effect was indicated for opioid craving. Most studies were hampered by inadequate reporting details and heterogeneity, thus future well-designed studies are needed to confirm the efficacy of acupuncture in opioid addiction treatment.
All Author(s) ListWu S.L.Y., Leung A.W.N., Yew D.T.W.
Journal nameEast Asian Archives of Psychiatry
Volume Number26
Issue Number2
PublisherHong Kong Academy Press
Place of PublicationChina
Pages70 - 76
LanguagesEnglish-United Kingdom
KeywordsAcupuncture, Electroacupuncture, Heroin, Opioid-related disorders, Substance withdrawal syndrome

Last updated on 2022-16-01 at 23:56