Mortality and its risk factors in patients with rapid eye movement sleep behavior disorder
Publication in refereed journal

替代計量分析
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其它資訊
摘要Study Objectives:
To determine the mortality and its risk factors in patients with rapid eye movement (REM) sleep behavior disorder (RBD).

Methods:
A total of 205 consecutive patients with video-polysomnography confirmed RBD (mean age = 66.4 ± 10.0 y, 78.5% males) were recruited. Medical records and death status were systematically reviewed in the computerized records of the health care system. Standardized mortality ratio (SMR) was used to calculate the risk ratio of mortality in RBD with reference to the general population.

Results:
Forty-three patients (21.0%) died over a mean follow-up period of 7.1 ± 4.5 y. The SMR was not increased in the overall sample, SMR (95% confidence interval [CI]) = 1.00 (0.73–1.33). However, SMR (95% CI) increased to 1.80 (1.21–2.58) and 1.75 (1.11–2.63) for RBD patients in whom neurodegenerative diseases and dementia, respectively, eventually developed. In the Cox regression model, mortality risk was significantly associated with age (hazard ratio [HR] = 1.05; 95% CI, 1.01–1.10), living alone (HR = 2.04; 95% CI, 1.39–2.99), chronic obstructive pulmonary disease (HR = 3.38; 95% CI, 1.21–9.46), cancer (HR = 10.09; 95% CI, 2.65–38.42), periodic limb movements during sleep (HR = 3.06; 95% CI, 1.50–6.24), and development of neurodegenerative diseases (HR = 2.84; 95% CI, 1.47–5.45) and dementia (HR = 2.66; 95% CI, 1.39–5.08).

Conclusions:
Patients with RBD have a higher mortality rate than the general population only if neurodegenerative diseases develop. Several risk factors on clinical and sleep aspects are associated with mortality in RBD patients. Our findings underscore the necessity of timely neuroprotective interventions in the early phase of RBD before the development of neurodegenerative diseases.
著者Zhou J., Zhang J., Lam S.P., Mok V., Chan A., Xin Li S., Liu Y., Tang X., Yung W.H., Wing Y.K.
期刊名稱SLEEP
出版年份2016
月份8
日期1
卷號39
期次8
出版社The American Academy of Sleep Medicine
出版地United States
頁次1543 - 1550
國際標準期刊號0161-8105
電子國際標準期刊號1550-9109
語言英式英語
關鍵詞Mortality, Neurodegenerative disease, REM sleep behavior disorder, SMR

上次更新時間 2020-18-10 於 01:53