Add-on tests for improving risk-stratification in emergency department patients with chest pain who are at low to moderate risk of 30-day major adverse cardiac events
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摘要Background Chest pain patients commonly present to emergency departments (ED), and require either hospital admission and/or lengthy diagnostic protocols to rule-out myocardial infarction. We aimed to identify the best combination of add-on tests to high-sensitivity cardiac troponin (hs-cTnT) for predicting 30-day major adverse cardiac events (MACE) in adult chest pain patients presenting to an ED with suspected acute coronary syndrome. Methods This prospective observational study was conducted in the ED of a tertiary university hospital in Hong Kong, recruiting adult patients with chest pain of less than 24 h duration, suspected with acute coronary syndrome (ACS), and had no history of coronary artery bypass grafting or stent insertion. Patients underwent triage assessment, electrocardiography, blood sampling for laboratory hs-cTnT, and Thrombolysis in Myocardial Infarction (TIMI) and HEART score assessment. The primary outcome was the number of patients with 30-day MACE. Results 602 consecutive patients were recruited and completed 30-day follow-up. A 30-day MACE occurred in 42 (7.0%) patients. Out of 12 possible models for stratifying patients at risk of 30-day MACE within 2 h of ED arrival, a combination of electrocardiography (ECG) and one-time hs-cTnT (model 5) provided the simplest and most accurate model. A risk score of 0 to 5 was derived from raw coefficients of model 5. The risk score provided excellent calibration (P = 0.91) and discrimination (AUC 0.87, 95% CI: 0.82 to 0.93). Conclusion Appropriate early risk-stratification of patients with chest pain and possible ACS using a combination of ECG and one-time hs-cTnT may improve efficiency of care.
著者Rainer T.H., Leung Y.K., Lee A., Chan P.Y., Cheng N.M., Wong J.K., Yan B.P., Ahuja A.T., Graham C.A.
期刊名稱International Journal of Cardiology
出版年份2016
月份10
日期1
卷號220
出版社Elsevier BV
出版地Netherlands
頁次299 - 306
國際標準期刊號0167-5273
電子國際標準期刊號1874-1754
語言英式英語
關鍵詞Acute coronary syndrome, ECG, HEART score, hs-cTnT, MACE, TIMI score

上次更新時間 2020-16-09 於 02:39