Hypoxia causes transgenerational impairments in reproduction of fish
Publication in refereed journal

香港中文大學研究人員
替代計量分析
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其它資訊
摘要Hypoxia is amongst the most widespread and pressing problems in aquatic environments. Here we demonstrate that fish (Oryzias melastigma) exposed to hypoxia show reproductive impairments (retarded gonad development, decrease in sperm count and sperm motility) in F1 and F2 generations despite these progenies (and their germ cells) having never been exposed to hypoxia. We further show that the observed transgenerational reproductive impairments are associated with a differential methylation pattern of specific genes in sperm of both F0 and F2 coupled with relevant transcriptomic and proteomic alterations, which may impair spermatogenesis. The discovered transgenerational and epigenetic effects suggest that hypoxia might pose a dramatic and long-lasting threat to the sustainability of fish populations. Because the genes regulating spermatogenesis and epigenetic modifications are highly conserved among vertebrates, these results may also shed light on the potential transgenerational effects of hypoxia on other vertebrates, including humans.
著者Wang S.Y., Lau K., Lai K.-P., Zhang J.-W., Tse A.C.-K., Li J.-W., Tong Y., Chan T.-F., Wong C.K.-C., Chiu J.M.-Y., Au D.W.-T., Wong A.S.-T., Kong R.Y.-C., Wu R.S.-S.
期刊名稱Nature Communications
出版年份2016
月份7
日期4
卷號7
出版社Nature Publishing Group
出版地United Kingdom
國際標準期刊號2041-1723
語言英式英語

上次更新時間 2020-16-09 於 02:39