Accelerated failure time model under general biased sampling scheme
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AbstractRight-censored time-To-event data are sometimes observed from a (sub)cohort of patients whose survival times can be subject to outcome-dependent sampling schemes. In this paper, we propose a unified estimation method for semiparametric accelerated failure time models under general biased estimating schemes. The proposed estimator of the regression covariates is developed upon a bias-offsetting weighting scheme and is proved to be consistent and asymptotically normally distributed. Large sample properties for the estimator are also derived. Using rank-based monotone estimating functions for the regression parameters, we find that the estimating equations can be easily solved via convex optimization. The methods are confirmed through simulations and illustrated by application to real datasets on various sampling schemes including length-bias sampling, the case-cohort design and its variants.
All Author(s) ListKim J.P., Sit T., Ying Z.
Journal nameBiostatistics
Volume Number17
Issue Number3
PublisherOxford University Press
Place of PublicationUnited Kingdom
Pages576 - 588
LanguagesEnglish-United Kingdom
KeywordsAccelerated failure time model, Case-cohort design, Counting process, Estimating equations, Importance sampling, Length-bias, Regression, Survival data

Last updated on 2020-27-03 at 03:51