Application of multimodal MR imaging on studying Alzheimer's disease: A survey
Publication in refereed journal


摘要The aim of this review is to summarize the current magnetic resonance imaging (MRI) variants applied on the studies of Alzheimer's disease (AD). Experimental findings, advantages and disadvantages, and the prospect of every individual technique will be presented. MRI can be used to investigate the change of the brain in terms of volume, function, white matter track orientation and even mechanical properties and metabolic concentration.Results from volumetric and morphological analysis indicated that the hippocampus reduced by approximately 18%-24% or 3%-4% annually. Functional MRI (fMRI) detected the blood oxygen level dependent (BOLD) signaland suggested thatmedial temporal lobe (MTL) such as hippocampus and entorhinal cortex reduced at the early stage of AD, and frontal, temporal, and parietal cortices at the later stage. In diffusion tensor imaging (DTI), the white matter fiber track integrity is measured but the results are inconsistent. Besides,magnetic resonance spectroscopy (MRS), chemical shift imaging (CSI), arterial spin labeling (ASL), magnetic resonance elastography (MRE) and susceptibility weighted imaging (SWI) will also be included in this review. © 2013 Bentham Science Publishers.
著者Wang D., Hui S.C.N., Shi L., Huang W.-H., Wang T., Mok V.C.T., Chu W.C.W., Ahuja A.T.
期刊名稱Current Alzheimer Research
出版社Bentham Science Publishers
出版地United Arab Emirates
頁次877 - 892
關鍵詞Alzheimer's disease, Amyloid, DTI, fMRI, MRS, Multimodal MRI, Tau pathology

上次更新時間 2020-24-11 於 00:10