Genome-wide association study identifies novel susceptible loci and highlights Wnt/beta-catenin pathway in the development of adolescent idiopathic scoliosis
Publication in refereed journal


摘要The genetic architecture of adolescent idiopathic scoliosis (AIS) remains poorly understood. Here we present the result of a 4-stage genome-wide association study composed of 5,953 AIS patients and 8,137 controls. Overall, we identified three novel susceptible loci including rs7593846 at 2p14 near MEIS1 (Pcombined = 1.19 × 10-13, OR = 1.21, 95% CI = 1.10-1.32), rs7633294 at 3p14.1 near MAGI1 (Pcombined = 1.85 × 10-12, OR = 1.20, 95% CI = 1.09-1.32), and rs9810566 at 3q26.2 near TNIK (Pcombined = 1.14 × 10-11, OR = 1.19, 95% CI = 1.08-1.32). We also confirmed a recently reported region associated with AIS at 20p11.22 (Pcombined = 1.61 × 10-15, OR = 1.22, 95% CI = 1.12-1.34). Furthermore, we observed significantly asymmetric expression of Wnt/beta-catenin pathway in the bilateral paraspinal muscle of AIS patients, including beta-catenin, TNIK, and LBX1. This is the first study that unveils the potential role of Wnt/beta-catenin pathway in the development of AIS, and our findings may shed new light on the etiopathogenesis of AIS.
著者Zezhang Zhu,Leilei Xu, Nelson Leung-Sang Tang, Xiaodong Qin, Zhenhua Feng, Weixiang Sun, Weiguo Zhu, Benlong Shi, Peng Liu, Saihu Mao, Jun Qiao, Zhen Liu, Xu Sun, Fangcai Li, Jack Chun-Yiu Cheng, Yong Qiu
期刊名稱Human Molecular Genetics
出版社Oxford University Press
頁次1577 - 1583
關鍵詞single nucleotide polymorphism, genetics, genome-wide association study, adolescent idiopathic scoliosis, beta catenin

上次更新時間 2020-15-08 於 01:31